2-Arachidonoylglycerol (2-AG)

2-Arachidonoylglycerol, also known as 2-AG, is a extensively researched endocannabinoid that plays a crucial role in maintaining body’s internal balance, known as homeostasis. Discovered in 1995, it was identified as a naturally occurring ligand for cannabinoid receptors within the body. The primary function of 2-AG is to act as a neuromodulator, effectively functioning as a “messenger” when it binds to CB1 and CB2 receptors located throughout the body, thus activating specific functions. Notably, 2-AG is found in elevated concentrations in the central nervous system, where it plays a pivotal role in regulating neurons in the brain and the nervous system. Beyond this, 2-AG is involved in various physiological processes, including neuroinflammation, cognition, emotional regulation, pain management, energy balance, stress response, and more. Its significance in these functions makes it a fundamental element in the body’s overall well-being.