Anandamide

Anandamide is a naturally occurring long-chain polyunsaturated fatty acid molecule within the human body, serving as a vital component of the endocannabinoid system. This compound plays a crucial role in various biological functions, including mood regulation, memory processing, appetite control, pain perception, and inflammation reduction. Functioning as a ligand, anandamide binds to specific receptors, eliciting specific responses in the body. Notably, it activates CB1 and CB2 receptors, as well as type 1 Vanilloid receptors, which are associated with the elimination of cancerous cells. The discovery of anandamide dates back to 1992 when Israeli scientists, led by Raphael Mechoulam, first identified it. Initially known as arachidonylethanolamide, the compound was later renamed “anandamide” after the Sanskrit term “ananda,” which translates to “bliss” or “divine happiness.” In the body, anandamide is broken down by an enzyme called fatty acid amide hydrolase (FAAH) into smaller components, preventing its accumulation and maintaining the balance of the endocannabinoid system.