In 1992, three researchers from Hebrew University in Jerusalem made the groundbreaking discovery of the endocannabinoid system (ECS). This system is the largest receptor system in the body and serves as the primary regulator of homeostasis. Through interactions with the brain, endocrine system, and immune system, the ECS maintains balance throughout the body. It achieves this regulatory function with the help of its CB1 and CB2 receptors.
CB receptors can be found in neurons within the central nervous system and in immune cells throughout the peripheral nervous system. The ECS is often described as a “retrograde system,” meaning it regulates various systems through a negative feedback loop. This involves the activation of postsynaptic synthesis, followed by the release of endocannabinoids that target specific cannabinoid receptors.
Despite its importance, the ECS remains a complex and not fully understood system. However, experts believe that it plays a fundamental role in the proper functioning of the body.